Professionals transitioning into a workplace face the challenge of socializing into their new working communities. One important factor in this process is humor. We present a case study of how a newcomer transitioning towards integral status interacts with the use of humor in her new workplace. Using the Communities of Practice framework, we examine workplace discourse collected from a new recruit, Emma, and her colleagues in a Hong Kong firm. The analysis portrays a picture of how humor is a critical (...) element as Emma negotiates relationships with other colleagues and works towards her assigned tasks. Findings suggest that humor can be an indicator to newcomers of appropriate or inappropriate behavior. Humor can be used for newcomers’ integration into the workplace; humor can be used by integral members to mold newcomers into the normative ways of doing things. We argue that humor may be used as a regulating and coping mechanism in workplace socialization. (shrink)

Volume 1 of the _Routledge History of Philosophy_ covers one of the most remarkable periods in human thought. In the space of two and a half centuries, philosophy developed from quasi-mythological speculation to a state in which many of the most fundamental questions about the universe, the mind and human conduct had been vigorously pursued, and some of the most enduring masterworks of Western thought had been written. The essays present the fundamental approaches and thinkers of Greek philosophy in chronological (...) order. Each is written by a recognised authority in the particular field, and takes account of the large amount of high-quality work done in the last few decades on Platonic and pre-Platonic philosophy. All write in an accessible style, meeting the needs of the non-specialist without loss of scholarly precision. Topics covered range from early Greek speculative thought, its cultural and social setting, to the Sophists, Socrates and culminate in three chapters on Plato's lasting contribution to all central areas of philosophy. Supplemented with a chronology, a glossary of technical terms and an extensive bibliography, this volume will prove an invaluable and comprehensive guide to the beginnings of philosophy. (shrink)

This first volume in the series traces the development of philosophy over two-and-a-half centuries, from Thales at the beginning of the sixth century BC to the death of Plato in 347 BC.

Socrates has a unique position in the history of philosophy. His influence on Plato is credited with the development of Western philosophy. In this book Christopher Taylor explores the relationship between the historical Socrates and the Platonic character--and examines the enduring image of Socrates as the ideal exemplar of the philosophic life.

Provides a critical and analytical history of ancient Greek theories on the nature of pleasure, and of its value and rolein human lfie, from the ealriest times down to the period of Epicurus and the early Stoics.

Freedom to innovate in teaching and learning are essential to meaningful higher education. Universities’ rhetorical commitments to freedom and innovation are ubiquitous and quite homogenous. Beneath the rhetoric, however, lie sharp divides between neo-liberal and Humboldtian approaches to innovation, course design, teaching and learning. This article argues that to understand the authentic approach of a university to innovation requires going beyond the rhetoric. We must instead examine context-specific experiences and understandings of the curriculum, especially in terms of teaching, learning, assessment (...) and evaluation. Making this critical examination, we see that Humboldtian frameworks rely on broad understandings of value connected to learners and their communities. Neoliberal frameworks by contrast reduce and essentialise these understandings to customer service provision. Treating students as customers has significant implications for how innovation is defined and enacted through increasing aversion to the risks inherent to attempting innovation. Quality evaluation and assurance processes inevitably align with an institution’s authentic approach, regardless of what rhetorical commitments suggest. The article concludes by suggesting ways forward grounded in teaching, learning and evaluation. These are congruent with a Humboldtian approach and may, through their application bring the rhetoric of teaching and learning innovation into alignment with experienced reality. (shrink)

Current theories suggest that the brain is the sole source of mental illness. However, affective disorders, and major depressive disorder (MDD) in particular, may be better conceptualized as brain-body disorders that involve peripheral systems as well. This perspective emphasizes the embodied, multifaceted physiology of well-being, and suggests that afferent signals from the body may contribute to cognitive and emotional states. In this review, we focus on evidence from preclinical and clinical studies suggesting that afferent thermosensory signals contribute to well-being and (...) depression. Although thermoregulatory systems have traditionally been conceptualized as serving primarily homeostatic functions, increasing evidence suggests neural pathways responsible for regulating body temperature may be linked more closely with emotional states than previously recognized, an affective warmth hypothesis. Human studies indicate that increasing physical warmth activates brain circuits associated with cognitive and affective functions, promotes interpersonal warmth and prosocial behavior, and has antidepressant effects. Consistent with these effects, preclinical studies in rodents demonstrate that physical warmth activates brain serotonergic neurons implicated in antidepressant-like effects. Together, these studies suggest that (1) thermosensory pathways interact with brain systems that control affective function, (2) these pathways are dysregulated in affective disorders, and (3) activating warm thermosensory pathways promotes a sense of well-being and has therapeutic potential in the treatment of affective disorders. (shrink)

This Open Access book combines philosophical and historical analysis of various forms of alternatives to mechanism and mechanistic explanation, focusing on the 19th century to the present. It addresses vitalism, organicism and responses to materialism and its relevance to current biological science. In doing so, it promotes dialogue and discussion about the historical and philosophical importance of vitalism and other non-mechanistic conceptions of life. It points towards the integration of genomic science into the broader history of biology. It details a (...) broad engagement with a variety of nineteenth, twentieth and twenty-first century vitalisms and conceptions of life. In addition, it discusses important threads in the history of concepts in the United States and Europe, including charting new reception histories in eastern and south-eastern Europe. While vitalism, organicism and similar epistemologies are often the concern of specialists in the history and philosophy of biology and of historians of ideas, the range of the contributions as well as the geographical and temporal scope of the volume allows for it to appeal to the historian of science and the historian of biology generally. (shrink)

How do people use past experience to generalise to novel cases? This paper reports four experiments exploring the significance on one class of past experiences: encounters with negative or contrasting cases. In trying to decide whether all ravens are black, what is the effect of learning about a non-raven that is not black? Two experiments with preschool-aged, young school-aged, and adult participants revealed that providing a negative example in addition to a positive example supports generalisation. Two additional experiments went on (...) to ask which kinds of negative examples offer the most support for generalisations. These studies contrasted similarity-based and category-based accounts of inductive generalisation. Results supported category-based predictions, but only for preschool-aged children. Overall, the younger children showed a greater reliance on negative evidence than did older children and adults. Most things we encounter in the world are negative evidence for our generalisations. Understanding the role of negative evidence is central for psychological theories of inductive generalisation. (shrink)

This paper explores the notions of hope and how individual patient autonomy can trump carefully reasoned ethical concerns and policies intended to regulate stem cell transplants. We argue that the same limits of knowledge that inform arguments to restrain and regulate unproven treatments might also undermine our ability to comprehensively dismiss or condemn them. Incautiously or indiscriminately reasoned policies and attitudes may drive critical information and data underground, impel patients away from working with clinical researchers, and tread needlessly on hope, (...) the essential motivator of patients, advocates and researchers alike. We offer recommendations to clinicians and health care providers to help balance the discourse with individuals seeking treatment while guarding against fraud, misconception, and patient harm. (shrink)

Many individuals with disabling conditions have difficulty with gait and balance control that may result in a fall. Exoskeletons are becoming an increasingly popular technology to aid in walking. Despite being a significant aid in increasing mobility, little attention has been paid to exoskeleton features to mitigate falls. To develop improved exoskeleton stability, quantitative information regarding how a user reacts to postural challenges while wearing the exoskeleton is needed. Assessing the unique responses of individuals to postural perturbations while wearing an (...) exoskeleton provides critical information necessary to effectively accommodate a variety of individual response patterns. This report provides kinematic and neuromuscular data obtained from seven healthy, college-aged individuals during posterior support surface translations with and without wearing a lower limb exoskeleton. A 2-min, static baseline standing trial was also obtained. Outcome measures included a variety of 0 dimensional measures such as center of pressure RMS, peak amplitude, velocities, pathlength, and electromyographic RMS, and peak amplitudes. These measures were obtained during epochs associated with the response to the perturbations: baseline, response, and recovery. T-tests were used to explore potential statistical differences between the exoskeleton and no exoskeleton conditions. Time series waveforms of the COP and EMG data were also analyzed. Statistical parametric mapping was used to evaluate the 1D COP and EMG waveforms obtained during the epochs with and without wearing the exoskeleton. The results indicated that during quiet stance, COP velocity was increased while wearing the exoskeleton, but the magnitude of sway was unchanged. The OD COP measures revealed that wearing the exoskeleton significantly reduced the sway magnitude and velocity in response to the perturbations. There were no systematic effects of wearing the exoskeleton on EMG. SPM analysis revealed that there was a range of individual responses; both behaviorally and among neuromuscular activation patterns. Using both the OD and 1D measures provided a more comprehensive representation of how wearing the exoskeleton impacts the responses to posterior perturbations. This study supports a growing body of evidence that exoskeletons must be personalized to meet the specific capabilities and needs of each individual end-user. (shrink)

This volume brings together eminent theologians, philosophers and political theorists to discuss such questions as how religious understandings have shaped the moral landscape of contemporary culture; the possible contributions of theology and theologically informed moral argument to contemporary public life; the problem of religious and moral discourse in a pluralistic society; and the proper relationship between religion and culture.

This paper explores the notions of hope and how individual patient autonomy can trump carefully reasoned ethical concerns and policies intended to regulate stem cell transplants. We argue that the same limits of knowledge that inform arguments to restrain and regulate unproven treatments might also undermine our ability to comprehensively dismiss or condemn them. Incautiously or indiscriminately reasoned policies and attitudes may drive critical information and data underground, impel patients away from working with clinical researchers, and tread needlessly on hope, (...) the essential motivator of patients, advocates and researchers alike. We offer recommendations to clinicians and health care providers to help balance the discourse with individuals seeking treatment while guarding against fraud, misconception, and patient harm. (shrink)

Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take as input integration site data from our INSPIIRED pipeline. Paired-end sequencing allows inference of the numbers of transduced cells as well as the distributions of integration sites in target genomes. We present interactive heatmaps that allow comparison of distributions of integration sites to (...) genomic features and that support numerous user-defined statistical tests. To summarize integration site data from human gene therapy samples, we developed a reproducible report format that catalogs sample population structure, longitudinal dynamics, and integration frequency near cancer-associated genes. We also introduce a novel summary statistic, the UC50, which provides a single number summarizing possible clonal expansion. Using these tools, we characterize ongoing longitudinal characterization of a patient from the first trial to treat severe combined immunodeficiency-X1, showing successful reconstitution for 15 years accompanied by persistence of a cell clone with an integration site near the cancer-associated gene CCND2. Software is available at https://github.com/BushmanLab/INSPIIRED. (shrink)

We argue that the use of the term “supernatural” is problematic in philosophy of religion in general, and in the contribution by Thornhill-Miller and Millican in particular. We address the disturbing parallel between Hume’s case against the rationality of belief in miracles and his dismissal of reports of racial equality. We do not argue that because Hume was a racist therefore his view against miracles is faulty, but we draw attention to how Hume sets up a framework that, for similar (...) reasons, discounts evidence of black intelligence and divine intelligence. We go on to argue against TMM’s revision of Hume on miracles. We then argue that empirical testing on the veracity of petitionary belief is impossible for there is no control case and that empirical testing can no more evaluate the evidential merits of most religious experiences than it can assess the merits of any robust philosophical position in epistemology, metaphysics, value theory, logic and mathematics. We express doubts about the integrity and scope of how one might enjoy the good of religion without belief. In a final section we offer a defense of the rationality of believing in specific religious traditions based on religious experience along with what we refer to as sufficient philosophical reasoning. (shrink)

We point out how some Christian-Muslim comparative philosophies of religion may be enhanced with certain translations or interpretations of Christianity: a modalist view of the trinity and a high Christology. While perhaps of only limited significance, we argue in more detail that a comparison of two leading philosophers, one Islamic, the other Christian, can bring to light a shared philosophy of innate ideas or nativism, grounding moral and theological views of goodness and the divine.

When people want to identify the causes of an event, assign credit or blame, or learn from their mistakes, they often reflect on how things could have gone differently. In this kind of reasoning, one considers a counterfactual world in which some events are different from their real-world counterparts and considers what else would have changed. Researchers have recently proposed several probabilistic models that aim to capture how people do (or should) reason about counterfactuals. We present a new model and (...) show that it accounts better for human inferences than several alternative models. Our model builds on the work of Pearl (2000), and extends his approach in a way that accommodates backtracking inferences and that acknowledges the difference between counterfactual interventions and counterfactual observations. We present six new experiments and analyze data from four experiments carried out by Rips (2010), and the results suggest that the new model provides an accurate account of both mean human judgments and the judgments of individuals. (shrink)

Nicht zuletzt der Krieg in der Ukraine zeigt die herausragende Bedeutung des Weltraumes für unsere Gesellschaft sowie die militärische Operationsführung im Allgemeinen. Bereits in 2019 wurde durch die NATO dieser Bedeutung Rechnung getragen, in dem der Weltraum als fünfte Dimension neben Luft, Land, See und Cyber anerkannt wurde. Die für den Weltraum notwendige Infrastruktur wird gemeinhin als kritisch betrachtet und fällt damit auch unter die Abschreckungssystematik der NATO. Der Beitrag diskutiert die Abschreckungspolitik der NATO im Kontext Weltraum entlang der zwei (...) vorherrschenden Paradigmen – deterrence by punishment und deterrence by denial. In der Folge wird diskutiert, inwieweit die Förderung einer tragfähigen Responsive Space-Mentalität und deren Umsetzung in anwendbare Strategien von wesentlicher Bedeutung für die Übertragung auf eine kollektive Abschreckungsstrategie der NATO sein wird. Reaktionsfähige Weltraumkapazitäten werden es allen Mitgliedstaaten ermöglichen, zu den kollektiven Verteidigungsanstrengungen des Bündnisses beizutragen und den Grundsatz der deterrence by denial zu stärken. (shrink)

Background: Therapeutic misconception, the misunderstanding of differences between research and clinical care, is widely prevalent among non-incarcerated trial participants. However, little attention has been paid to its presence among individuals who participate in research while incarcerated. Methods: This study examined the extent to which 72 incarcerated individuals may experience therapeutic misconception about their participation in one of six clinical trials, and its correlation with participant characteristics and potential influences on research participation. Results: On average, participants endorsed 70% of items suggestive (...) of therapeutic misconception. The tendency toward therapeutic misconception was significantly higher among African Americans and Latinos compared to Whites, among older and less educated participants, and among enrollment in a substance-abuse-related trial; it was also correlated with a belief that the trial was the only way to obtain needed treatment. Conclusions: Therapeutic misconception may be particularly high among select incarcerated individuals and is associated with a perceived lack of treatment options. Further examination of therapeutic misconception among incarcerated research participants is needed. (shrink)

This article deals with two aspects of psychoanalytic history. The first is the history of ideas, specifically the notions of a one- and two-person psychology that are in such wide use today. Second, the authors attend, much more critically, to a disturbance of memory (repeated distortion, omission, selective representation, and misrepresentation) that has accompanied scholarly discussion of these ideas for the past 50 years. Finally, the authors attempt to restore the original meaning of the person-psychology concept and illustrate its relevance (...) for contemporary psychoanalytic debate. (shrink)

Over the past decade, we have witnessed some early signs of progress in the battle against international bribery and corruption, a problem that throughout the history of commerce had previously been ignored. We present a model that we then use to assess progress in reducing bribery. The model components include both hard law and soft law legislation components and enforcement and compliance components. We begin by summarizing the literature that convincingly argues that bribery is an immoral and unethical practice and (...) that the economic harm it causes falls most heavily on those least able to absorb it. The next section summarizes the main provisions of anti-bribery legislation including the Foreign Corrupt Practices Act (FCPA), the Organization for Eco nomic Development's Convention on Combating Bribery of Foreign Officials in International Business Transactions, the United Nations Convention Against Corruption and the laws of selected countries. We conclude this section with a discussion of the "moral imperialism" argument for not imposing Western laws and values on other cultures. The next section focuses on the roles played by NGOs including Transparency International (TI), the World Economic Forum (WEF), and the International Chamber of Commerce. We review trends in enforcement and prosecution, including a review of the United States' enforcement processes, mechanisms for cross-border legal assistance, a discussion of the distinctive nature of FCPA cases, and an assessment of what the future holds for enforcement. The final section focuses on compliance processes for corporations aimed at reducing the risk of FCPA and related violations. This section also addresses the ethics of gift giving and "grease" payments. The article concludes with a summary and suggestions for further research. Throughout the article, we reference important bribery cases and include comments from several authorities who are on the front lines of the battle against international bribery. (shrink)

As a 2006 Institute of Medicine report highlights, surprisingly little empirical attention has been paid to how prisoners arrive at decisions to participate in modern research. With our study, we aimed to fill this gap by identifying a more comprehensive range of factors as reported by prisoners themselves during semistructured interviews. Our participants described a diverse range of motives, both favoring and opposing their eventual decision to join. Many are well-recognized considerations among nonincarcerated clinical research participants, including a desire for (...) various forms of personal benefit, altruism, and concern about study risks and inconveniences. However, a number of influences seem unique to prisoners. Participants did not report that they were not coerced into enrolling, and they have even been under pressure not to enroll. However, many sought to enroll in order to obtain access to better health care, raising a concern about whether they were unfairly exploited. (shrink)

Does the decision to relax by taking a drive rather than by taking a walk cause harm? In particular, do the additional carbon emissions caused by such a decision make anyone worse off? Recently several philosophers have argued that the answer is no, and on this basis have gone on to claim that act-consequentialism cannot provide a moral reason for individuals to voluntarily reduce their emissions. The reasoning typically consists of two steps. First, the effect of individual emissions on the (...) weather is miniscule: the planet’s meteorological system is so large, and the size of individual emissions so tiny, that whatever impact an individual emission has on the weather must be vanishingly small. Second, vanishingly small impacts aren’t morally relevant because no one could possibly tell the difference between such an impact occurring and it not occurring. In this paper, we show why both steps are mistaken, and hence why act-consequentialism implies that each of us has an individual obligation to do what we can to stop damaging the climate, including by refraining from, or perhaps by purchasing offsets against, our own individual luxury carbon emissions. (shrink)

After almost a year and a half of the COVID-19 pandemic, many healthcare institutions in the United States announced that they would mandate COVID-19 vaccination, with medical and religious exceptions, as a term of employment. The mandates resulted in widely publicized protests from hospital staff, including some nurses, who argued that these medical institutions violated the ethical principle of autonomy. As the world enters the “post-pandemic period,” decisions such as these, made during times of crisis, must be reviewed to provide (...) clarity for when the next pandemic occurs. In this paper, we support the argument that such mandates are ethically justifiable. We explore the framework of objections that were brought forward by dissenters of this vaccine mandate. Next, we provide an analysis of conflicting ethical principles present when such mandates were deployed. Utilizing the American Nurses Association’s Code of Ethics for Nurses, notably provisions 2, 3, and 6 we argue that it is an ethical duty of the nurse to be vaccinated. Specifically, we turn to provision two, which most explicitly underscores the necessity of vaccination as a function of the nurse’s primary commitment to the patient. Next, we highlight the International Council of Nurses Code of Ethics which provides similar guidance internationally. Finally, we examine the applicability of the principles of public health, care ethics, and the nursing role as frameworks to underpin such mandates both for the current and for potential future pandemics, arguing that the nurse’s ethical duty to be vaccinated spans these contexts. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

Over the past decade, a series of studies have found that physicians-in-training who work extended shifts are at increased risk of experiencing motor vehicle crashes, needlestick injuries, and medical errors. In response to public concerns and a request from Congress, the Institute of Medicine conducted an inquiry into the issue and concluded in 2009 that resident physicians should not work for more than 16 consecutive hours without sleep. They further recommended that the Centers for Medicare & Medicaid Services and the (...) Joint Commission work with the Accreditation Council for Graduate Medical Education to ensure effective enforcement of new work hour standards.The IOM's concerns with enforcement stem from well-documented non-compliance with the ACGME's 2003 work hour rules, and the ACGME's history of non-enforcement. In a nationwide cohort study, 84% of interns were found to violate the ACGME's 2003 standards in the year following their introduction. (shrink)

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

_Action Dharma_ charts the emergence of a new chapter in an ancient faith - the rise of social service and political activism in Buddhist Asia and the West. Fourteen new essays treat the historical origins, global range, teachings and practices, and leaders and organizations that make up the latest turning of the Dharma. Environmentalism and peace walks through the minefields of Southeast Asia, the future of the 'untouchables' of Japan, and outreach to minorities and inmates of the criminal justice system (...) in the West are some of the challenging topics considered. (shrink)

Charles Taylor is currently one the most renowned and influential contemporary philosophers. He is also widely quoted and discussed both in the social sciences and humanities. Taylor earns this attention through his remarkable capacity for presenting his conceptions in the broadest possible intellectual and cultural context. His philosophical intuition is fundamentally antinaturalistic, and tends toward developing broad syntheses without a trace of systematizing thinking, or any anarchic postmodernist methodology. His thought unites the past with the present, while culture is (...) treated as a broad mosaic of discourses. Religion, art, science, philosophy, politics and ethics are all fields through which the Canadian philosopher deftly moves about in his search for their hidden structures and deepest sense. Taylor's philosophical output is prodigious. Recently, as his monumental study A Secular Age (2007) indicates, he has been concentrating much of his attention on the problem of secularization.. The selection of contributions in the current volume proffer a penetrating cross section of Taylor's thought. They are derived from a conference held in October 2008 in Lublin, Poland Although some of the articles are focused on a reconstruction of the philosopher's concepts, most either engage in a polemic with elements of his thought or find inspiration in it for their own reflections. The contributions are grouped in four parts: 1) philosophy and the modern self; 2) the problem of secularization; 3) between liberalism and communitarianism; and 4) language, literature, and culture. (shrink)